This study found that people with mild cognitive impairment had their cognitive decline slowed by taking B vitamins. The modest doses used were easy to replicate. 800 mcg Folic Acid. 500 mcg B-12, 20 mg B-6 and they took them for two years.Benefits seen? Significant improvements in homocysteine levels, in global cognition, episodic memory, delayed recall and semantic memory. Progression of memory impairment was slowed in the B vitamin group and not at all in the placebo group.
de Jager, Jacoby et al, 'Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial', International Journal of Geriatric Psychiatry, 2011.
