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Monday, April 1, 2013

Vitamin D deficiency increases risk of type 2 Diabetes.


This study investigated whether baseline vitamin D level is associated with the incidence of type 2 diabetes in high-risk subjects for up to 5 years of follow-up, independently of obesity, baseline insulin resistance, and β cell function. Participants were 1080 nondiabetic Korean subjects based on the presence of one or more risk factors for type 2 diabetes, including obesity, hypertension, dyslipidemia, and/or family history of type 2 diabetes. Of the participants, 10.5% had a serum vitamin D deficiency (<10 ng/mL), 51.6% had an insufficiency (10.0-19.9 ng/mL), and 38.0% had a sufficiency (≥20 ng/mL), and the incidence of type 2 diabetes at 32.3 months declined accordingly: 15.9%, 10.2%, and 5.4%, respectively. After adjustment for age, sex, blood pressure, lifestyles, family history, season, parathyroid hormone, and high-sensitivity C-reactive protein, the participants with vitamin D deficiency had an increased risk of type 2 diabetes (106% increase for vitamin D levels 10-19.9 ng/mL compared with ≥20 ng/mL and 223% for vitamin D level <10 ng/mL compared with ≥20 ng/mL) independently of BMI, HOMA2-IR, and insulinogenic index. The authors conclude "The current prospective study suggests that vitamin D metabolism may play a role in type 2 diabetes pathogenesis independently of known risk factors".

Lim S, Kim MJ, Choi SH, Shin CS, Park KS, Jang HC, Billings LK, Meigs JB. Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr. 2013 Mar;97(3):524-30.

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