Best pandemic advice: maintain healthy levels of vitamin D!

 

New research shows insufficient blood levels of vitamin D might heighten people's odds for severe or even fatal COVID-19.

Maintaining a healthy level of vitamin D may "reduce the complications, including the cytokine storm (release of inflammatory proteins into the blood too quickly) and ultimately death from COVID-19," according to the study author Dr. Michael Holick. Dr. Holick is a professor of medicine, physiology, biophysics and molecular medicine at Boston University School of Medicine. 

Vitamin D is called the "sunshine vitamin" because it's produced by a cholesterol compound in the skin when skin is exposed to sunlight. But it can also be sourced through certain foods and supplements. 

The findings build upon those of prior research.

Several studies have found that patients with vitamin D deficiency have a worse outcome in COVID-19. Vitamin D has a beneficial effect on the immune system.

Holick and his colleagues assessed vitamin D levels in blood samples from 235 hospitalized COVID-19 patients. The blood samples were also checked for an inflammatory marker called C-reactive protein and for the number of lymphocytes, (immune cells that fight infections.)

Patients who were vitamin D-sufficient -- a blood level of at least 30 nanograms per milliliter -- had a significantly lower risk for serious complications from COVID-19, including losing consciousness, low blood oxygen levels and death. 

Among patients older than 40, those who were vitamin D-sufficient were also 51.5% less likely to die from COVID-19 compared to those who were vitamin D-deficient or insufficient, the team said. 

The study was published Sept. 25 in the journal PLOS ONE.
A prior study by Holick found that having a sufficient amount of vitamin D might also reduce the risk of becoming infected with the new coronavirus by 54%. Along with reducing the risks associated with the new coronavirus, being vitamin D-sufficient does the same against other viruses that cause upper respiratory tract illnesses, including the flu, according to Holick. 

"There is great concern that the combination of an influenza infection and a coronal viral infection could substantially increase hospitalizations and death due to complications from these viral infections," he said in a university news release. 

All in all, vitamin D could offer a simple and cost-effective way to combat the new coronavirus, Holick believes. "Because vitamin D deficiency and insufficiency is so widespread in children and adults in the United States and worldwide, especially in the winter months, it is prudent for everyone to take a vitamin D supplement to reduce risk of being infected and having complications from COVID-19," he said. 

In people who don't take D, the level is usually low, so it may make sense to take D as a supplement. A blood test will reveal your level of vitamin D. Supplements should be in the most bioavailable form of vitamin D, vitamin D-3. A typical adult dose is 4000 to 5000 iu daily.

 

Why We Need Immune-Boosting Vitamin D Right Now

Immune-boosting vitamin D3 is extremely important right now. But why stop at vitamin D? I also advise daily doses of vitamin C, magnesium, omega-3s, and NAC.

Here’s why vitamin D3 is at the top of the list. It plays a central role in supporting our immune system, making all of our immune cells more toxic against invading pathogens. Our white blood cells make chemicals called cytotoxins. These frontline immune cells engulf bacteria or viruses and use those cytotoxins to kill the invaders. 

The role of vitamin D is this: cytotoxins are more lethal to pathogens when vitamin D levels are higher. Vitamin D also facilitates the maturation of monocytes (juvenile white blood cells) into macrophages (the white blood cells that gobble up pathogens and then destroy them).

Vitamin D3 also promotes our body’s production of cathelicidins and defensins, antimicrobial immune warriors that help keep our lungs safe from viral and bacterial infections. Cathelicidin overpowers respiratory viruses like influenza A, which may explain the seasonal fluctuation in influenza that follows the seasonal strength of sunlight, our native source of vitamin D. Cathelicidin also defeats the tuberculosis bacterium which may explain why, in earlier times, people who had tuberculosis were sent to sunnier climates and their health improved.

We are facing a pandemic now, involving a novel coronavirus that attacks the lungs and sometimes leads to severe pneumonia or even acute respiratory distress syndrome in a minority of vulnerable persons. For some, the infection is mild, for others it can be fatal. 

While there have not yet been studies using vitamin D against this coronavirus, there is reason to be positive about the protection vitamin D might offer. Previous studies have shown us that through multiple mechanisms, vitamin D can reduce the risk of infections. Those mechanisms include inducing the previously mentioned cathelicidins and defensins. They can lower viral replication rates and reduce concentrations of pro-inflammatory cytokines (chemicals produced by our cells) that produce the inflammation that injures the lining of the lungs, leading to pneumonia. 

Cathelicidins and defensins also increase concentrations of anti-inflammatory cytokines. Since one of the observations in the current pandemic is of overactive immune responses, described as “cytokine storms,” vitamin D’s ability to calm the storm and return the immune response to balance may prove to be crucial.

Experts such as members of the Vitamin D Council suggest that during the next several months to possibly years, we should strive to get our serum vitamin D levels to a target of 40-60 ng/mL. Normal 25OH D levels range between 30 ng/mL and 100 ng/mL.

On average, adults need a daily intake of 5,000-10,000 IU of vitamin D3 to achieve a serum level in the midrange of normal, or 40-60 ng/mL

Please note magnesium supplementation is recommended when taking vitamin D supplements. Magnesium helps activate vitamin D, which in turn helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. The dose of magnesium should be in the range of 250–500 mg/d, along with twice that dose of calcium. 

Iron supports a healthy immune system.

Iron is important for immune function yet it is one of the most common nutrient deficiencies. Here are many reasons why you should check iron levels at your next checkup.

Iron plays an essential role in normal development of the immune system and resistance to infection. Impaired immunocompetence is associated with iron deficiency.  Ref. Ref. 

Iron is  necessary for immune cell production, cytokine production, ref, immune response 
  and the generation of reactive oxygen species required for killing pathogens. Ref Ref

Iron deficiency is associated with some reduced function of lymphoid organs (tissues that produce lymphocytes) and immune cells, specifically thymus degeneration, resulting in a decrease of T cells. Ref.

Iron deficiency is associated with reduced neutrophil activity against bacteria. Myeloperoxidase, an enzyme in neutrophils required for killing bacteria, needs iron to function. Ref. 

Neutrophil function is restored to normal with iron supplementation. Ref. Ref.

Low iron is linked to changes in immune responses that reduce the ability to fight off viral and bacterial infections. Ref.

Iron deficiency is associated with impairments in cell mediated immunity and innate immunity and may render older adults more vulnerable to infections. Ref.

A growing understanding of the connection between our gut and our brain.

Although the interaction between our brain and gut has been studied for years, its complexities run deeper than initially thought. It seems that our minds are, in some part, controlled by the bacteria in our bowels.

The gut has defenses against pathogens, but, at the same time, it encourages the survival and growth of "healthy" gut bacteria.

Of course, these bacteria do benefit from the warmth and nutrition in our bowels, but it is not a one-way relationship - they also give back.

Some species benefit us by breaking dietary fiber down into short-chain fatty acids that we can then absorb and use. They metabolize a number of compounds on our behalf and play a role in the synthesis of  vitamins B and K.

On the other hand, recent research infers that imbalance of gut bacteria might be an important factor in inflammatory and autoimmune conditions.

The microbiome's role in health and disease is only slowly giving up its secrets. The latest and perhaps most remarkable finding is the ability that gut bacteria have to moderate our brain and behavior.

The links between our gut and brain are hormonal, immunological, and neural, via the central nervous system and the enteric nervous system, which governs the function of the gut. Collectively, they are termed the gut-brain axis.

These gut-brain conversations have been studied for some time. However, a new level to this partnership has recently been glimpsed; researchers are now considering the influence of our microbiome on the gut-brain axis. In other words, researchers are asking: do the bacteria in our gut affect our psychology and behavior?

The question is whether adding beneficial gut bacteria to an animal can make a difference. Research seems to say yes.

A study published in the Journal of Neurogastroenterology and Motility, collated the results of studies looking at the effects of probiotics on central nervous system function in both humans and animals.

They examined 25 animal and 15 human studies, most of which used Bifidobacterium and Lactobacillus over a 2-4-week period. Although, as the authors mention, translating animal studies like this into human terms is a dodgy game. They concluded: "These probiotics showed efficacy in improving psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder, obsessive compulsive disorder and memory abilities, including spatial and non-spatial memory."

Making Choices that Slow Aging Significantly

Have you heard about telomeres? At the end of your chromosomes or DNA strands, you have protective caps called telomeres (imagine the little caps at the end of your shoelaces).

The length of your telomeres can tell you either how quickly or how slowly you are aging. Telomeres also shed light on the strength of your immune system. Their length indicates your risk of death and disease, including heart disease and cancer. Having short telomeres even points to higher risk of dementia.

In people who are older than 60 researchers have shown that those with shorter telomeres are eight times more likely to die from infectious diseases and three times more likely to die from heart disease. Although all telomeres shorten with age, an unhealthy lifestyle is linked to significantly greater telomere shortening. Researchers studying telomeres believe that lifespan may be increased by as much as five to ten years by changing habits that impact telomere length. Here are the most important choices you can make to protect your telomeres.

Knock out inflammation, and eat an antioxidant rich diet.

Chronic inflammation and oxidative stress caused by free radicals sabotage health, longevity and telomere length. Eating foods that contain lots of antioxidants and anti-inflammatory compounds helps prevent this double whammy of damage.

Be sure your diet includes abundant colorful fruits and vegetables like berries, cherries, pomegranates,  beets, oranges, and apples. And load up on dark green vegetables like collard greens and kale. Choose daily servings of orange veggies like carrots and sweet potato. And enjoy nuts, seeds, beans, fatty fish (salmon, rainbow trout, sardines), herbs, spices, 100% whole grains. Drink green or black tea and cook at low temperatures with extra virgin olive oil.

In terms of supplements, research suggests that vitamin D may improve telomere maintenance. Know your vitamin D levels by getting them checked at your annual check up. In the Sister Study, a daily multivitamin was also linked to longer telomeres in women. And of course if you don’t eat fatty fish at least twice a week, you should take a daily fish oil capsule. In the Heart And Soul study at the University of California, San Francisco involving over 600 outpatients with stable heart disease, individuals with the lowest intakes of marine source omega-3 fats experienced the most rapid rate of telomere shortening, whereas those with the highest intakes experienced the slowest rate of telomere shortening. Be sure you get at least 1000 mg daily of the EPA and DHA from cold water fish. And be sure the supplement you choose is tested and found to be free of harmful levels of compounds like mercury, lead, cadmium and PCBs. My fish oil brand is Carlson Laboratories.  Disclosure: I am their Senior Nutritionist and Educator. The folks at Carlson are seriously nice people, lucky me.

Eliminate added sugar, white bread, unhealthy fats and processed meat.

Some foods slow the aging process, others put aging on the fast track. Sugar, refined carbohydrates including white bread cakes cookies and crackers, unhealthy fats particularly trans fats and high omega-6 vegetable oils and processed meats are the most harmful. Based on data from the U.S. National Health and Nutrition Examination Survey involving over 5300 adults, drinking one sugar- sweetened soft drink daily accelerated aging as much as smoking. In a study of children and teens in Spain, white bread was the worst habit. In a study in Finland, involving almost 2000 elderly men and women, a high intake of saturated fat was linked to shorter telomeres.

Do whatever you must to stay at a healthy weight for your height.

At St. Thomas Hospital in the UK, obese women had telomeres that were significantly shorter than in lean women of the same age. This was not surprising. Fat cells are biologically active, and not in a good way. Fat secretes hormones that increase inflammation in the body and cause oxidative stress. ( Oh those two again!) Thus telomeres shorten, aging hits the gas pedal, and lifespans are shortened. Eat whole foods, be more active and work to reduce stress to keep your weight within a healthy range.

At the risk of being redundant. Stay active and reduce sitting time.
Moving your body several times everyday provides phenomenal health benefits, not the least of which is slamming the brakes on aging considerably. Daily activity boosts your resistance to infections, guards against chronic inflammation and helps to combat stress. You’ll get slim and you’ll be protecting the length of those all important telomeres. In one study that followed 2,400 twins, being regularly active during leisure time meant significantly longer telomeres (about 10 years younger biologically) compared to persons who were inactive.

Get up out of that chair! How much time you spend sitting also matters. In a 6 month study in Sweden, involving sedentary, overweight men and women, reducing sitting time resulted in significantly longer telomeres. Always aim for a minimum of 30 to 60 minutes of moderate to vigorous activity each day. Break up sitting time throughout the day and evening too. Sitting equals aging. Here’s an idea. Get up every 30 minutes and drink a small glass of water. (see what I did there?)

Watch your alcohol and never smoke cigarettes. If you smoke now is the time to quit.
Have you ever looked at people who smoke regularly or who drink excessively? They do not paint a pretty picture. They always look older than they should for their age. Heavy drinking and smoking ages you at a cellular level. The American Association for Cancer Research reported that telomere length was dramatically shorter (about half as long) in those who consumed heavy amounts of alcohol compared to those who did not. In a study reported in the UK, telomere shortening caused by smoking one pack of cigarettes a day for 40 years was equivalent to the loss of almost 71⁄2 years of life. Bottom line: don’t smoke and if you drink, do so only in moderation (one drink daily for women and two for men).

Defend your quality of sleep vigorously. Getting enough sleep (7 hours or more) and getting good quality sleep are both linked to longer telomeres. The older you are, the more significant this relationship is. Proper sleep helps repair telomeres and protects against damage caused by inflammation. Lack of sleep increases inflammation in the body significantly.

Zen extends life. If you’re chronically stressed out, anxious, lonely or depressed, your telomeres are probably shorter. If you have recently suffered a great loss, you’re also at risk. Stress hormones, like cortisol, make you gain weight around the middle, think belly fat. The hormone also damages cells and hastens aging. In a study involving healthy premenopausal women, those with the highest levels of perceived stress had telomeres shorter on average by the equivalent of at least 10 years of additional aging compared to low stress women. 

In a demonstration of all of the points made here today, a UC study found that telomere shortening was less pronounced  in high stress women if they exercised, ate well and got enough sleep. Good self-care must be a priority. 

There is also good news for meditators. Meditation also benefits telomere health. Om.

The Cancer Fighting/Promoting Power of Foods.

No single food can reduce your risk of cancer, but the right combination of foods may help make a difference. At mealtimes, strike a balance of at least 2/3 plant-based foods and no more than 1/3 animal protein. This "New American Plate" is an important cancer fighting tool, according to the American Institute for Cancer Research. Check out better and worse choices for your plate.

Fighting Cancer With Color

Fruits and vegetables are rich in cancer-fighting nutrients - and the more color, the more nutrients they contain. These foods can help lower your risk in a second way, too, when they help you reach and maintain a healthy body weight. Carrying extra pounds increases the risk for multiple cancers, including colon, esophagus, and kidney cancers. Aim for five to nine servings a day, prepared in a healthy way.

The Cancer-Fighting Breakfast

Folate is an important B vitamin that may help protect against cancers of the colon, rectum, and breast.  You can find it in abundance on the breakfast table. Fortified breakfast cereals and whole wheat products are good sources of folate. So are orange juice, melons, and strawberries. 

Folate the rest of the day.

Other good sources of folate are asparagus and eggs. You can also find it in chicken liver, beans, sunflower seeds, and leafy green vegetables like spinach or romaine lettuce. According to the ACS, the best way to get folate is not from a pill, but by eating enough fruits, vegetables, and enriched grain products.

Cancer Fighting Tomatoes.

Whether it's the lycopene -- the pigment that gives tomatoes their red color -- or something else isn't clear. But some studies have linked eating tomatoes to reduced risk of several types of cancer, including prostate cancer. Studies also suggest that processed tomato products such as juice, sauce, or paste increase the cancer-fighting potential.

Tea  especially green tea, may be a strong cancer fighter. In laboratory studies, green tea has slowed or prevented the development of cancer in colon, liver, breast, and prostate cells. It also had a similar effect in lung tissue and skin. And in some longer term studies, tea was associated with lower risks for bladder, stomach, and pancreatic cancers.

Grapes and grape juice, especially purple and red grapes, contain resveratrol. Resveratrol has strong antioxidant and anti-inflammatory properties. In laboratory studies, it has prevented the kind of damage that can trigger the cancer process in cells. There is not enough evidence to say that eating grapes or drinking grape juice or wine can prevent or treat cancer.

Water not only quenches your thirst, but it may protect you against bladder cancer. The lower risk comes from water diluting concentrations of potential cancer-causing agents in the bladder. Also, drinking more fluids causes you to urinate more frequently. That lessens the amount of time those agents stay in contact with the bladder lining.

Beans are so good for you, it's no surprise they may help fight cancer, too.  They contain several potent phytochemicals that may protect the body's cells against damage that can lead to cancer. In the lab these substances slowed tumor growth and prevented tumors from releasing substances that damage nearby cells.

Cruciferous vegetables include broccoli, cauliflower, cabbage, Brussels sprouts, bok choy, and kale. These members of the cabbage family make an excellent stir fry and can really liven up a salad. But most importantly, components in these vegetables may help your body defend against cancers such as colon, breast, lung, and cervix.

Dark green leafy vegetables such as mustard greens, lettuce, kale, chicory, spinach, and chard have an abundance of fiber, folate, and carotenoids. These nutrients may help protect against cancer of the mouth, larynx, pancreas, lung, skin, and stomach.

Curcumin is the main ingredient in the Indian spice turmeric and a potential cancer fighter. Lab studies show it can suppress the transformation, proliferation, and invasion of cancerous cells for a wide array of cancers.

How you cook meat can make a difference in how big a cancer risk it poses. Frying, grilling, and broiling meats at very high temperatures causes chemicals to form that may increase cancer risk. Other cooking methods such as stewing, braising, or steaming appear to produce fewer of those chemicals. And when you do stew the meat, remember to add plenty of healthy, protective vegetables.

Strawberries and raspberries have a phytochemical called ellagic acid. This powerful antioxidant may actually fight cancer in several ways at once, including deactivating certain cancer causing substances and slowing the growth of cancer cells.

The potent antioxidents in blueberries may have wide value in supporting our health, starting with cancer. Antioxidants fight cancer by ridding the body of free radicals before they can do their damage to cells. Try topping oatmeal, cold cereal, yogurt, even salad with blueberries to boost your intake of these healthful berries.

Sugar may not cause cancer directly. But it may displace other nutrient-rich foods that help protect against cancer. And it increases calorie counts, which contributes to overweight and obesity. Excess weight can be a cancer risk. Fruit offers a sweet alternative in a vitamin-rich package.

Limit alcohol to slash cancer risk. Cancers of the mouth, throat, larynx, esophagus, liver, and breast are all linked with drinking alcohol. Alcohol may also raise the risk for cancer of the colon and rectum. The American Cancer Society says that even the suggested daily limit of 2 drinks for men and 1 for women elevates the risk. Women at higher risk for breast cancer may want to talk with a doctor about what amount of alcohol, if any, is safe based on their personal risk factors.